Sodium Bicarbonate Tablets

Pronunciation: SO-dee-um bye-KAR-bo-nate
Generic Name: Sodium Bicarbonate
Brand Name: Generic only. No brands available.

Sodium Bicarbonate is used for:

Relieving indigestion, heartburn, sour stomach, or upset stomach.

Sodium Bicarbonate is an antacid. It works by neutralizing stomach acid, which helps relieve upset stomach.

Do NOT use Sodium Bicarbonate if:

• you are allergic to any ingredient in Sodium Bicarbonate


• you have appendicitis or a blockage of your bowel


• you are on a low-salt diet

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sodium Bicarbonate:

Some medical conditions may interact with Sodium Bicarbonate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of stomach or intestinal bleeding


• if you have congestive heart failure, edema, liver problems, kidney problems, or rectal bleeding from an unknown cause

Some MEDICINES MAY INTERACT with Sodium Bicarbonate. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anorexiants (eg, phentermine) or sympathomimetics (eg, pseudoephedrine) because side effects may be increased by Sodium Bicarbonate


• Azole antifungals (eg, fluconazole), cephalosporins (eg, cephalexin), lithium, or tetracyclines (eg, doxycycline) because effectiveness may be decreased by Sodium Bicarbonate

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sodium Bicarbonate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sodium Bicarbonate:

Use Sodium Bicarbonate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Sodium Bicarbonate may be taken with or without food.


• If you miss taking a dose of Sodium Bicarbonate for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember your dose every day.

Ask your health care provider any questions you may have about how to use Sodium Bicarbonate.

Important safety information:

• If your symptoms do not improve within 2 weeks or if they become worse, check with your doctor.


• Use Sodium Bicarbonate with caution in the ELDERLY because they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while using Sodium Bicarbonate, discuss with your doctor the benefits and risks of using Sodium Bicarbonate during pregnancy. It is unknown if Sodium Bicarbonate is excreted in breast milk. If you are or will be breast-feeding while you are using Sodium Bicarbonate, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Sodium Bicarbonate:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; headache; irritability; muscle rigidity; nausea; vomiting; weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Sodium Bicarbonate side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include alkalosis (muscle twitching or tremors, nausea, vomiting, numbness or tingling in the face or extremities, confusion possibly leading to coma); seizures.

Proper storage of Sodium Bicarbonate:

Store Sodium Bicarbonate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sodium Bicarbonate out of the reach of children and away from pets.

General information:

• If you have any questions about Sodium Bicarbonate, please talk with your doctor, pharmacist, or other health care provider.


• Sodium Bicarbonate is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sodium Bicarbonate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Sodium Bicarbonate resources

• Sodium Bicarbonate Side Effects (in more detail)
• Sodium Bicarbonate Dosage
• Sodium Bicarbonate Use in Pregnancy & Breastfeeding
• Drug Images
• Sodium Bicarbonate Drug Interactions
• Sodium Bicarbonate Support Group
• 0 Reviews for Sodium Bicarbonate - Add your own review/rating

Compare Sodium Bicarbonate with other medications

• Asystole
• Diabetic Ketoacidosis
• Hyperkalemia
• Hyperuricemia Secondary to Chemotherapy
• Indigestion
• Metabolic Acidosis
• Urinary Alkalinization

Atrial Tachycardia Medications

There are currently no drugs listed for "Atrial Tachycardia".

Definition of Atrial Tachycardia:

Paroxysmal tachycardia originating in an ectopic focus in the atrium.

Synonym: auricular tachycardia.

Learn more about Atrial Tachycardia

Micromedex Care Notes:

• Atrial Tachycardia
• Supraventricular Tachycardia

Medical Encyclopedia:

• Multifocal atrial tachycardia

Drug List:

Mometasone/Formoterol Inhalation Aerosol

Pronunciation: moe-MET-a-sone/for-MOE-ter-ol
Generic Name: Mometasone/Formoterol
Brand Name: Dulera

Long-acting beta-agonists such as one of the active ingredients in Mometasone/Formoterol Inhalation Aerosol (formoterol) have been rarely associated with an increased risk of asthma-related death. They may also increase the risk of asthma-related hospitalizations in CHILDREN and TEENAGERS. Mometasone/Formoterol Inhalation Aerosol should only be used to treat asthma patients who are not controlled by using other long-term asthma-control medicine. Mometasone/Formoterol Inhalation Aerosol should not be used in patients whose asthma is well controlled by inhaled corticosteroids.

Mometasone/Formoterol Inhalation Aerosol is used for:

Treating asthma in certain patients. It may also be used for other conditions as determined by your doctor.

Mometasone/Formoterol Inhalation Aerosol is a combination of a corticosteroid and a long-acting beta-agonist bronchodilator. The corticosteroid works by decreasing inflammation in the lungs. The long-acting beta-agonist works by widening the airways in the lungs, which helps you breathe more easily.

Do NOT use Mometasone/Formoterol Inhalation Aerosol if:

• you are allergic to any ingredient in Mometasone/Formoterol Inhalation Aerosol


• you are using another medicine that has a long-acting beta-agonist (eg, salmeterol) in it


• you are having an asthma attack (eg, sudden, severe onset or worsening of asthma symptoms such as wheezing, cough, chest tightness, shortness of breath)


• you have asthma that is already well controlled with the use of a long-term asthma-control medicine (eg, inhaled corticosteroid)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mometasone/Formoterol Inhalation Aerosol:

Some medical conditions may interact with Mometasone/Formoterol Inhalation Aerosol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of diabetes, heart problems (eg, fast, slow or irregular heartbeat, heart blood vessel problems), high blood pressure, high blood acid levels (ketoacidosis), low blood potassium levels, seizures, tuberculosis, a weakened immune system, liver problems, or thyroid problems


• if you have weakened bones (eg, osteoporosis), a family history of weakened bones, or have other risk factors of weak bones (eg, smoking, poor nutrition, you take certain medicines that weaken bones)


• if you have a history of eye problems (eg, glaucoma, cataracts, increased eye pressure)


• if you have diarrhea; a fungal, bacterial, or parasitic infection; a viral infection (eg, chickenpox, measles); herpes infection of the eye; or a lung infection (eg, pneumonia)


• if you have recently been to an emergency room for asthma, have a history of frequent hospitalizations for asthma, or have ever had a life-threatening asthma attack


• if you have had an unusual reaction to a sympathomimetic medicine (eg, albuterol, pseudoephedrine), such as fast or irregular heartbeat, overexcitement, or severe trouble sleeping


• if you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) or a tricyclic antidepressant (eg, amitriptyline), or if you have taken either of these medicines within the last 14 days

Some MEDICINES MAY INTERACT with Mometasone/Formoterol Inhalation Aerosol. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-agonists (eg, albuterol), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), or xanthines (eg, theophylline) because the risk of low blood potassium or irregular heartbeat may be increased


• Azole antifungals (eg, itraconazole, ketoconazole), HIV protease inhibitors (eg, atazanavir, indinavir, ritonavir), linezolid, other long-acting beta-agonists (eg, salmeterol), macrolide antibiotics (eg, clarithromycin), monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nefazodone, telithromycin, or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Mometasone/Formoterol Inhalation Aerosol's side effects


• Beta-blockers (eg, propranolol) because they may decrease Mometasone/Formoterol Inhalation Aerosol's effectiveness or worsen your condition

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mometasone/Formoterol Inhalation Aerosol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mometasone/Formoterol Inhalation Aerosol:

Use Mometasone/Formoterol Inhalation Aerosol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Mometasone/Formoterol Inhalation Aerosol comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Mometasone/Formoterol Inhalation Aerosol refilled.


• You will need to prime the inhaler before using it for the first time, any time it has not been used for more than 5 days, or if it has been dropped. To prime the inhaler, point it away from you and others. Spray 4 times, shaking well before each spray.


• Be sure that the canister is properly placed in the inhaler unit. Shake well before each use. Remove the mouthpiece cover. Check the mouthpiece for foreign objects. Breathe out slowly and completely. Place the mouthpiece between your lips and try to rest your tongue flat, unless your doctor has told you otherwise. Your doctor may have told you to hold the inhaler 1 or 2 inches (2 or 3 centimeters) away from the open mouth or to use a special spacing device. As you start to take a slow, deep breath, press the canister and mouthpiece together at exactly the same time. This will release a dose of Mometasone/Formoterol Inhalation Aerosol. Continue breathing in slowly and deeply and hold for as long as comfortable up to 10 seconds, then breathe out slowly through your nose while keeping your lips closed. If more than 1 inhalation is to be used, wait at least 30 seconds and repeat the above steps. Keep the spray away from your eyes. Close the mouthpiece cover after each use.


• Rinse your mouth with water after you finish using the medicine (do not swallow). This will help remove excess medicine and decrease your risk of developing an oral fungal infection.


• Wipe the mouthpiece clean with a dry cloth at least once a week.


• Use the new inhaler that comes with each refill. Do not reuse an old inhaler. Do not use Mometasone/Formoterol Inhalation Aerosol with a different kind of inhaler.


• Never wash the mouthpiece or any other part of the inhaler with water. Keep it dry and always store in a dry place. Do NOT try to take the inhaler apart.


• This inhaler contains 124 sprays. A dose counter shows how many puffs are left in the inhaler. Do not use this inhaler after 124 sprays have been used (when the counter on the inhaler says "0"). The inhaler may not feel empty, but you will not get the correct amount of medicine with each spray if you continue to use it.


• Continue to use Mometasone/Formoterol Inhalation Aerosol even if you feel well. Do not miss any doses.


• If you miss a dose of Mometasone/Formoterol Inhalation Aerosol, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Mometasone/Formoterol Inhalation Aerosol.

Important safety information:

• Mometasone/Formoterol Inhalation Aerosol is for oral inhalation only. Do not spray in the eyes. If you get Mometasone/Formoterol Inhalation Aerosol in the eyes, rinse immediately with cool tap water. If eye redness and irritation continue, contact your doctor.


• Mometasone/Formoterol Inhalation Aerosol may cause dizziness. This effect may be worse if you use it with alcohol or certain medicines. Use Mometasone/Formoterol Inhalation Aerosol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Some patients may have trouble using Mometasone/Formoterol Inhalation Aerosol correctly. Some may also get mouth sores or a bad taste in the mouth after using it. If you have any of these problems, ask your health care provider if a spacing device may help.


• The risk of serious heart problems (eg, irregular heartbeat) may be greater if you use Mometasone/Formoterol Inhalation Aerosol in high doses. Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Mometasone/Formoterol Inhalation Aerosol should be used to treat asthma only if your asthma is not well controlled while you are using a certain long-term asthma-control medicine (eg, inhaled corticosteroid) or if you have severe asthma. Contact your doctor if you have questions about this information.


• Use caution if you switch from an oral steroid (eg, prednisone) to Mometasone/Formoterol Inhalation Aerosol. It may take several months for your body to make enough natural steroids to handle events that cause physical stress. Such events may include injury, surgery, infection, loss of blood electrolytes, or a sudden asthma attack. These may be severe and sometimes fatal. Contact your doctor right away if any of these events occur. You may need to take an oral steroid (eg, prednisone) again. Carry a card at all times that says you may need an oral steroid (eg, prednisone) if any of these events occur.


• Mometasone/Formoterol Inhalation Aerosol may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. Tell your doctor right away if you are exposed to anyone who has these infections.


• Do not receive a live vaccine (eg, measles, mumps) while you are taking Mometasone/Formoterol Inhalation Aerosol. Talk with your doctor before you receive any vaccine.


• Mometasone/Formoterol Inhalation Aerosol will not stop an asthma attack once it has already started. Be sure to carry a short-acting bronchodilator inhaler (eg, albuterol) with you at all times to treat any breathing problems that may occur between doses of Mometasone/Formoterol Inhalation Aerosol (eg, severe or sudden onset of wheezing or shortness of breath). If you have any questions about which medicines stop asthma attacks, check with your doctor or pharmacist.


• If you have been regularly using a short-acting bronchodilator inhaler (eg, albuterol), talk with your doctor about how to use it with Mometasone/Formoterol Inhalation Aerosol. Short-acting bronchodilators are normally only used with Mometasone/Formoterol Inhalation Aerosol to treat breathing problems that may occur between doses.


• Tell your doctor or dentist that you take Mometasone/Formoterol Inhalation Aerosol before you receive any medical or dental care, emergency care, or surgery.


• If your symptoms do not get better within 1 to 2 weeks of starting Mometasone/Formoterol Inhalation Aerosol or if they get worse, contact your doctor right away.


• Tell your doctor at once if you notice that your short-acting bronchodilator inhaler does not work as well, if you need to use it often (eg, 4 or more times a day for more than 2 days in a row, more than 1 canister in 8 weeks), or if you have a decrease in your peak flow meter results.


• Contact your doctor or seek medical care right away if you have breathing problems that worsen quickly or if you use your short-acting bronchodilator and do not get relief.


• Talk with your doctor or pharmacist about all of your asthma medicines and how to use them. Your doctor may make changes to your asthma-control medicines once your asthma is well controlled. Do not start, stop, or change the dose of any asthma medicine unless your doctor tells you to.


• The medicine may sometimes cause breathing problems right after you use a dose. If this happens, use your short-acting bronchodilator. Contact your doctor or seek other medical care at once.


• Lab tests, including lung function, blood pressure, and eye exams, may be performed while you use Mometasone/Formoterol Inhalation Aerosol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Mometasone/Formoterol Inhalation Aerosol with caution in the ELDERLY; they may be more sensitive to its effects, especially weakened bones.


• Corticosteroids may affect the growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Mometasone/Formoterol Inhalation Aerosol.


• Mometasone/Formoterol Inhalation Aerosol should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is not known if Mometasone/Formoterol Inhalation Aerosol can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Mometasone/Formoterol Inhalation Aerosol while you are pregnant. It is not known if Mometasone/Formoterol Inhalation Aerosol is found in breast milk. If you are or will be breast-feeding while you use Mometasone/Formoterol Inhalation Aerosol, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Mometasone/Formoterol Inhalation Aerosol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; dry mouth; headache; nausea; nervousness; stuffy nose; throat irritation; tiredness; tremor; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; flushing of the skin; tightness in the chest; swelling of the mouth, face, lips, tongue, or throat; unusual hoarseness); chest pain; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; increased mucus production or change in color of mucus; muscle pain, weakness, or cramps; new or worsening asthma symptoms (eg, coughing, increased chest tightness, shortness of breath, wheezing); seizures; severe or persistent dizziness, headache, nervousness, or tremor; speech problems; vomiting; white patches in your mouth or throat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; fainting; fast or irregular heartbeat; fatigue; headache; increased thirst or urination; muscle pain or cramps; nausea; nervousness; seizures; severe or persistent dizziness or dry mouth; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; drowsiness; flushing of the skin; confusion; fruit-like breath odor); tremors; trouble sleeping; weakness.

Proper storage of Mometasone/Formoterol Inhalation Aerosol:

Store Mometasone/Formoterol Inhalation Aerosol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and direct sunlight. Do not store in the bathroom. Do not puncture, break, or burn the canister even if it appears to be empty. Keep Mometasone/Formoterol Inhalation Aerosol out of the reach of children and away from pets.

General information:

• If you have any questions about Mometasone/Formoterol Inhalation Aerosol, please talk with your doctor, pharmacist, or other health care provider.


• Mometasone/Formoterol Inhalation Aerosol is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Mometasone/Formoterol Inhalation Aerosol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Mometasone/Formoterol resources

• Mometasone/Formoterol Use in Pregnancy & Breastfeeding
• Mometasone/Formoterol Drug Interactions
• Mometasone/Formoterol Support Group
• 6 Reviews for Mometasone/Formoterol - Add your own review/rating

Compare Mometasone/Formoterol with other medications

• Asthma
• Asthma, Maintenance

Silodosin

Pronunciation: sil-OH-doe-sin
Generic Name: Silodosin
Brand Name: Rapaflo

Silodosin is used for:

Treating the signs and symptoms of enlarged prostate (benign prostatic hyperplasia [BPH]).

Silodosin is an alpha-blocker. It works by relaxing muscles in the prostate and bladder, which helps to improve urine flow and reduce symptoms of BPH.

Do NOT use Silodosin if:

• you are allergic to any ingredient in Silodosin


• you have severe kidney or liver problems


• you are taking ketoconazole, clarithromycin, itraconazole, nefazodone, or ritonavir


• you are taking another alpha-blocker (eg, prazosin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Silodosin:

Some medical conditions may interact with Silodosin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of blood pressure problems and you are taking blood pressure medication


• if you have a history of prostate cancer


• if you have kidney or liver problems


• if you will be having eye surgery (eg, cataract surgery)

Some MEDICINES MAY INTERACT with Silodosin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Alpha-blockers (eg, prazosin) or phosphodiesterase inhibitors (eg, sildenafil) because symptoms of low blood pressure (eg, severe dizziness, lightheadedness, and fainting) may occur


• Azole antifungals (eg, itraconazole, ketoconazole), clarithromycin, cyclosporine, diltiazem, erythromycin, fluconazole, nefazodone, probenecid, ritonavir, valproic acid, or verapamil because they may increase the risk of Silodosin's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Silodosin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Silodosin:

Use Silodosin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Silodosin. Talk to your pharmacist if you have questions about this information.


• Take Silodosin by mouth with a meal.


• If you miss a dose of Silodosin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss more than 2 dose of Silodosin, contact your doctor for instructions.

Ask your health care provider any questions you may have about how to use Silodosin.

Important safety information:

• Silodosin may cause drowsiness, dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Silodosin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Silodosin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Do not drive or perform other possibly unsafe tasks for 12 hours after your first dose of Silodosin or after any dose increase.


• Tell your doctor or dentist that you take Silodosin before you receive any medical or dental care, emergency care, or surgery.


• Silodosin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.


• Lab tests, including kidney or liver function, may be performed while you use Silodosin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Silodosin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is not known if Silodosin can cause harm to the fetus. It is not known if Silodosin is found in breast milk. Silodosin is not approved for use in women.

Possible side effects of Silodosin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Decreased sexual ability; diarrhea; dizziness; headache; lightheadedness; runny or stuffy nose; sinus inflammation; stomach pain; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; fainting; irregular heartbeat; prolonged, painful erection; severe of persistent dizziness; unusual bruising; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Silodosin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe or persistent dizziness or lightheadedness.

Proper storage of Silodosin:

Store Silodosin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Silodosin out of the reach of children and away from pets.

General information:

• If you have any questions about Silodosin, please talk with your doctor, pharmacist, or other health care provider.


• Silodosin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Silodosin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Silodosin resources

• Silodosin Side Effects (in more detail)
• Silodosin Use in Pregnancy & Breastfeeding
• Silodosin Drug Interactions
• Silodosin Support Group
• 29 Reviews for Silodosin - Add your own review/rating

• Silodosin Professional Patient Advice (Wolters Kluwer)


• Silodosin Monograph (AHFS DI)


• silodosin Advanced Consumer (Micromedex) - Includes Dosage Information


• Rapaflo Prescribing Information (FDA)


• Rapaflo Consumer Overview

Compare Silodosin with other medications

• Benign Prostatic Hyperplasia

sorafenib

soe-RAF-e-nib

Commonly used brand name(s)

In the U.S.

• Nexavar

Available Dosage Forms:

• Tablet

Therapeutic Class: Antineoplastic Agent

Uses For sorafenib

Sorafenib is an anticancer medicine that is used to treat adults with kidney cancer (advanced renal cell carcinoma) and liver cancer that cannot be treated with surgery.

sorafenib is available only with your doctor's prescription.

Before Using sorafenib

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For sorafenib, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to sorafenib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of sorafenib in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sorafenib in the elderly. However, elderly patients are more likely to be sensitive and may require a lower dose.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking sorafenib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using sorafenib with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Cisapride


• Dronedarone


• Fluconazole


• Levomethadyl


• Mesoridazine


• Pimozide


• Posaconazole


• Saquinavir


• Sparfloxacin


• Thioridazine


• Ziprasidone

Using sorafenib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfuzosin


• Amiodarone


• Amitriptyline


• Amoxapine


• Apomorphine


• Arsenic Trioxide


• Asenapine


• Astemizole


• Azithromycin


• Chloroquine


• Chlorpromazine


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clomipramine


• Clozapine


• Crizotinib


• Dasatinib


• Desipramine


• Disopyramide


• Dofetilide


• Dolasetron


• Droperidol


• Erythromycin


• Flecainide


• Gatifloxacin


• Gemifloxacin


• Granisetron


• Halofantrine


• Haloperidol


• Ibutilide


• Iloperidone


• Imipramine


• Lapatinib


• Levofloxacin


• Lopinavir


• Lumefantrine


• Mefloquine


• Methadone


• Moxifloxacin


• Neomycin


• Nilotinib


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Ondansetron


• Paliperidone


• Pazopanib


• Perflutren Lipid Microsphere


• Procainamide


• Prochlorperazine


• Promethazine


• Propafenone


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Ranolazine


• Salmeterol


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sotalol


• Sunitinib


• Telavancin


• Telithromycin


• Terfenadine


• Tetrabenazine


• Toremifene


• Trazodone


• Trifluoperazine


• Trimipramine


• Vandetanib


• Vardenafil


• Vemurafenib


• Voriconazole

Using sorafenib with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Docetaxel


• Doxorubicin


• Irinotecan


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of sorafenib. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding problems or


• Heart disease or


• Hypertension (high blood pressure) or


• Stomach or bowel problems (e.g., perforation)—Use with caution. May make these conditions worse.

• Congestive heart failure or


• Electrolyte imbalance (e.g., high or low calcium, magnesium, or potassium) or


• Heart rhythm problems (e.g., QT prolongation, slow heartbeat)—Use with caution. May increase risk for more serious side effects.

• Heart rhythm problem (congenital long QT syndrome)—Should not be used in patients with this condition.

• Kidney disease, severe (requires dialysis) or


• Liver disease, severe—Use with caution. sorafenib has not been studied in patients with these conditions.

• Squamous cell lung cancer—Should not be used in combination with certain cancer medicines (e.g., carboplatin, paclitaxel, Paraplatin®, or Taxol®) in patients with this condition.

Proper Use of sorafenib

Medicines used to treat cancer are very strong and can have many side effects. Before using sorafenib, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Take sorafenib exactly as directed even if you feel well. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Swallow the tablet whole with water. Do not crush, break, or chew it.

Take the tablet on an empty stomach, at least 1 hour before or 2 hours after a meal.

sorafenib comes with a patient information insert. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Dosing

The dose of sorafenib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of sorafenib. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For kidney cancer:
    
    • Adults—400 milligrams (mg) two times a day. Your doctor may adjust your dose as needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For liver cancer:
    
    • Adults—400 milligrams (mg) two times a day. Your doctor may adjust your dose as needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of sorafenib, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using sorafenib

If you will be taking sorafenib for a long time, it is very important that your doctor check you at regular visits for any problems or unwanted effects that may be caused by sorafenib.

Your blood pressure should be checked weekly, especially during the first six weeks of starting sorafenib. Your doctor may need to treat you if you develop high blood pressure while you are using sorafenib. Symptoms of high blood pressure are blurred vision, dizziness, nervousness, headache, pounding in the ears, or a slow or fast heartbeat.

Using sorafenib while you are pregnant can harm your unborn baby. Men and women should use an effective form of birth control during treatment with sorafenib and for at least 2 weeks after stopping treatment. If you think you have become pregnant while using sorafenib, tell your doctor right away.

sorafenib may cause a serious skin problem called hand-foot syndrome. Check with your doctor right away if you have a skin rash or any redness, pain, swelling, or blisters on the palms of your hands or the soles of your feet. If you get this skin problem, your doctor may adjust the dose or stop treatment for a short time.

Sorafenib may cause serious heart problems. Stop using sorafenib and check with your doctor right away if you are having chest pain or discomfort; nausea; pain or discomfort in your arms, jaw, back or neck; shortness of breath; sweating; or vomiting.

Stop using sorafenib and check with your doctor right away if you start having severe abdominal or stomach burning, cramps, or pains; bloody or black, tarry stools; trouble breathing; heartburn; indigestion; nausea; or vomiting of material that looks like coffee grounds. These could be symptoms of a serious bowel problem.

sorafenib may increase your chance of bleeding and cause delay in wound healing. To help with this problem, stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

sorafenib can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Make sure any doctor who treats you knows that you are using sorafenib. You may need to stop using sorafenib several days before having surgery.

Before you have any medical tests, tell the medical doctor in charge that you are taking sorafenib. The results of some tests may be affected by sorafenib.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.

sorafenib Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Abdominal or stomach pain


• bleeding gums


• bloating of the abdomen or stomach


• blood in the urine or stools


• blurred vision


• clay-colored stools


• coughing up blood


• dark urine


• difficulty with breathing or swallowing


• dizziness


• headache


• increased menstrual flow or vaginal bleeding


• light-colored stools


• nausea and vomiting


• nervousness


• nosebleeds


• paralysis


• pounding in the ears


• prolonged bleeding from cuts


• red or black, tarry stools


• red or dark brown urine


• shortness of breath


• slow or fast heartbeat


• vomiting of blood


• yellow eyes or skin

Less common

• Bone pain


• chest pain or discomfort


• chills


• clammy skin


• confusion


• constipation


• convulsions (seizures)


• cough


• decreased urine production


• depressed mood


• difficulty with moving


• dry skin and hair


• enlarged pupils


• feeling cold


• fever


• hair loss


• hearing loss


• hives


• hoarseness or husky voice


• increased sensitivity of the eyes to light


• increased sweating, possibly with fever or cold


• increased thirst


• indigestion


• itching


• joint pain


• loss of appetite


• lower back or side pain


• muscle cramps and stiffness


• muscle pain


• pain or discomfort in the arms, jaw, back, or neck


• painful or difficult urination


• pains in the stomach, side, or abdomen, possibly radiating to the back


• pale skin


• pinpoint red spots on the skin


• reddening of the skin, especially around the ears


• ringing, buzzing, or other unexplained noise in the ears that continues


• severe chest pain


• severe headache


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• stiff or sore neck


• stomach discomfort, upset, or pain


• sweating


• swelling of the ankles or hands


• swelling of the eyes, face, or inside of the nose


• swollen glands


• swollen joints


• trouble breathing with exertion


• unpleasant breath odor


• unusual bleeding or bruising


• unusual tiredness or weakness


• weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Blistering, peeling, redness, and/or swelling of the palms of the hands or bottom of the feet


• burning, tingling, numbness or pain in the hands, arms, feet, or legs


• diarrhea


• numbness, pain, tingling, or unusual sensations in palms of the hands or bottom of the feet


• sensation of pins and needles


• stabbing pain


• thinning of the hair


• tightness in the chest


• weight loss


• wheezing

Less common

• Acid or sour stomach


• acne


• belching


• blistering, peeling, or loosening of the skin


• burning feeling in the chest or stomach


• burning, itching, and pain in hairy areas


• cracked lips


• cracks in the skin


• decreased appetite


• decreased interest in sexual intercourse


• discouragement


• dry mouth


• fainting


• feeling of warmth


• feeling sad or empty


• flushing or red skin


• gas


• general feeling of discomfort or illness


• heartburn


• inability to have or keep an erection


• increase in heart rate


• irritability


• lack or loss of strength


• lightheadedness


• loss in sexual ability, desire, drive, or performance


• loss of ability to use or understand speech or language


• loss of heat from the body


• loss of interest or pleasure


• mouth pain


• pus at the root of the hair


• rapid breathing


• red face, neck, arms, and occasionally, upper chest


• red, irritated eyes


• red, swollen skin


• runny nose


• scaly skin


• shivering


• skin rash that is encrusted, scaly, and oozing


• sunken eyes


• swelling of the breasts or breast soreness in both men and women


• swelling or inflammation of the mouth


• tenderness in the stomach area


• thirst


• trouble concentrating


• trouble sleeping


• unusually warm skin


• wrinkled skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: sorafenib side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More sorafenib resources

• Sorafenib Side Effects (in more detail)
• Sorafenib Dosage
• Sorafenib Use in Pregnancy & Breastfeeding
• Sorafenib Drug Interactions
• Sorafenib Support Group
• 3 Reviews for Sorafenib - Add your own review/rating

• Nexavar Prescribing Information (FDA)


• Nexavar Consumer Overview


• Nexavar Monograph (AHFS DI)


• Sorafenib MedFacts Consumer Leaflet (Wolters Kluwer)


• Sorafenib Professional Patient Advice (Wolters Kluwer)

Compare sorafenib with other medications

• Hepatic Tumor
• Hepatocellular Carcinoma
• Renal Cell Carcinoma
• Thyroid Cancer

CRIXIVAN 200 mg Capsules

CRIXIVAN 200 mg hard capsules

indinavir

Read all of this leaflet carefully before you start taking this medicine.

• Keep this leaflet. You may need to read it again.


• If you have any further questions, ask your doctor or your pharmacist.


• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.


• If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

In this leaflet:

1. What CRIXIVAN is and what it is used for

2. Before you take CRIXIVAN

3. How to take CRIXIVAN

4. Possible side effects

5. How to store CRIXIVAN

6. Further information

What Crixivan Is And What It Is Used For

Pharmacotherapeutic Group

CRIXIVAN is a member of a class of medicinal products called protease inhibitors. It is active against the Human Immunodeficiency Virus (HIV) helping to reduce the number of HIV particles in blood.

Therapeutic Indications

CRIXIVAN should be used in combination with other antiretroviral agents for the treatment of HIV–1 infected adult and paediatric patients.

CRIXIVAN has been shown to help reduce the risk of developing illnesses associated with HIV disease. CRIXIVAN has also been shown to help lower the amount of HIV in your body (called “viral load”) and raise your CD4 (T) cell count. CD4 cells play a role in maintaining a healthy immune system to help fight infection. CRIXIVAN may not have these effects in all patients.

Before You Take Crixivan

Do not take CRIXIVAN

• if you are allergic (hypersensitive) to indinavir or any of the other ingredients of CRIXIVAN.
  Signs and symptoms of an allergic reaction may include: itchy skin, redness of the skin, wheals or hives, swelling of the face, lips, tongue and/or throat, or difficulty breathing.

Do not take CRIXIVAN with or without ritonavir

• if you take products containing rifampicin, amiodarone, terfenadine, astemizole, cisapride, alprazolam, triazolam, oral (taken by mouth) midazolam (used to help you sleep and/or to relieve anxiety), pimozide and ergot derivatives such as ergot tartramine and ergot tartramine with caffeine, St. John's wort (Hypericum perforatum), simvastatin or lovastatin.

In addition, do not take CRIXIVAN with ritonavir

• if you take products containing alfuzosin, meperidine, piroxicam, propoxyphene, bepridil, encainide, flecanide, propafenone, quinidine, fusidic acid, clozapine, clorazepate, diazepam, estazolam, and flurazepam.


• If you have decompensated liver disease.

When CRIXIVAN is used with ritonavir, please tell your doctor and refer to the package leaflet for ritonavir for more information.

Take special care with CRIXIVAN

You should know that CRIXIVAN is not a cure for HIV infection and that you may continue to develop infections or other illnesses associated with HIV disease. You should, therefore, remain under the care of your doctor while taking CRIXIVAN.

HIV infection is a disease spread by contact with blood or sexual contact with an infected individual. Treatment with CRIXIVAN has not been shown to reduce the risk of transmission of HIV to others through sexual contact or blood contamination.

Please speak with your doctor if you have a history of liver disease. Patients with chronic hepatitis B or C and treated with antiretroviral agents are at increased risk for severe and potentially fatal liver adverse events and may require blood tests for control of liver function.

Redistribution, accumulation or loss of body fat may occur in patients receiving combination antiretroviral therapy. Contact your doctor if you notice changes in body fat.

Bone problems

Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone). The length of combination antiretroviral therapy, corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index, among others, may be some of the many risk factors for developing the disease. Signs of osteonecrosis are joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement. If you notice any of these symptoms please inform your doctor.

In some patients with advanced HIV infection (AIDS) and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started. It is believed that these symptoms are due to an improvement in the body’s immune response, enabling the body to fight infections that may have been present with no obvious symptoms. If you notice any symptoms of infection, please inform your doctor immediately.

Tell your doctor

• about any past or present medical problems, including liver disease due to cirrhosis;


• if you have kidney problems (including back pain with or without blood in your urine);


• if you have allergies;


• if you have high cholesterol and if you are taking cholesterol−lowering medicines called “statins”;


• if you have diabetes;


• if you have haemophilia;


• if you are intolerant to lactose because each hard capsule contains 74.8 mg lactose (anhydrous).

Children

CRIXIVAN can be taken by children 4 years of age and older who are able to swallow hard capsules.

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

There are some medicines that should not be taken with CRIXIVAN with or without ritonavir (see ‘Do not take CRIXIVAN’) or that require dosage changes of that medicine or CRIXIVAN (e.g., itraconazole, ketoconazole, ciclosporin, nevirapine, delavirdine and efavirenz).

Consult your doctor before taking certain cholesterol–lowering medicines (e.g., atorvastatin, rosuvastatin, pravastatin, fluvastatin), antifungals (e.g., fluconazole), anticonvulsants (e.g., phenobarbital, phenytoin, carbamazepine), steroids (e.g., dexamethasone), protease inhibitors (e.g., amprenavir, saquinavir, atazanavir), medicines for impotence (e.g., sildenafil), blood thinners (e.g., warfarin), calcium channel blockers (e.g., amlodipine, felodipine - class of medicinal products used for the treatment of hypertension and some specific heart disorders), sedative agents (e.g. midazolam administered by injection), antidepressants (e.g., venlafaxine), oral contraceptives (e.g., "the Pill"), medicines for asthma (e.g., theophylline) or any other medicines.

CRIXIVAN may be taken with a number of medicines that are commonly used in HIV infection (zidovudine, didanosine, lamivudine, stavudine, quinidine, cimetidine, clarithromycin, isoniazid, fluconazole, trimethoprim/sulfamethoxazole, methadone).

Some medications may interact with CRIXIVAN taken in combination with ritonavir. Please consult with your physician regarding taking medications with CRIXIVAN and ritonavir.

Taking CRIXIVAN with food and drink

CRIXIVAN should be taken without food but with water. If co-administered with ritonavir, CRIXIVAN may be administered with or without food.

If water is not preferred, CRIXIVAN can be taken with skimmed or low–fat milk, juice, coffee, or tea.

If CRIXIVAN cannot be taken without food, a low–fat light meal, such as dry toast with jam or fruit conserve, juice and coffee with skimmed or low–fat milk and sugar, or a light meal such as corn flakes with skimmed or low–fat milk and sugar is acceptable.

Taking CRIXIVAN with a meal that is high in calories, fat, and protein reduces your body’s ability to absorb the medicine and in turn reduces its effectiveness.

Pregnancy and breast-feeding

Tell your doctor if you are pregnant or intend to become pregnant.

If you are pregnant, you should take CRIXIVAN only if your doctor decides it is clearly needed.

It is not known whether CRIXIVAN is harmful to an unborn baby when taken by a pregnant woman.

Tell your doctor if you are breast−feeding.

It is recommended that HIV-infected women do not breast-feed their infants under any circumstances in order to avoid transmission of HIV.

Driving and using machines

There is no specific information to suggest that CRIXIVAN affects your ability to drive and use machinery. However, dizziness and blurred vision have been reported during treatment with CRIXIVAN. Do not drive or operate machines if you experience these symptoms.

Important information about some of the ingredients of CRIXIVAN

This medicinal product contains 299.2 mg of lactose in each 800-mg dose (maximum single dose). If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

How To Take Crixivan

Always take Crixivan exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. The usual dose for adults is 800 mg every 8 hours. An alternative dosing schedule for adults is CRIXIVAN 400 mg with ritonavir 100 mg both administered orally twice a day.

The dose for children and adolescents will be determined by the doctor.

For all dosages, use a combination of the 100–mg, 200–mg or 400–mg hard capsules, as appropriate.

CRIXIVAN must be taken at regular intervals of 8 hours for full effectiveness and either 1 hour before
or 2 hours after a meal.

CRIXIVAN should be swallowed unchewed together with water.

It is important for adults to drink at least 1.5 litres (approximately 48 fluid ounces) of liquids during each day while taking CRIXIVAN to help reduce the risk of forming kidney stones. It is also important for children and adolescents to drink enough liquids during the course of the day. The doctor will tell you the amount of liquids your child should drink.

Your doctor will tell you how long the treatment with CRIXIVAN will last.

If you take more CRIXIVAN than you should

In clinical studies, doses higher than 800 mg every 8 hours have not been shown to have any better effect.

Contact your doctor if you have taken more than the prescribed dose of CRIXIVAN. The most common signs and symptoms of overdose are: nausea, vomiting, diarrhoea, back pain and blood in the urine. There is at present little information on the treatment of overdosage.

If you forget to take CRIXIVAN

If you have missed a dose, do not take it later in the day. Simply continue to follow your usual schedule.

If you stop taking CRIXIVAN

It is important that you take CRIXIVAN exactly as your doctor prescribes. Do not stop taking it because reducing or missing doses will increase the risk of the HI–Virus becoming resistant to CRIXIVAN, in which case treatment with this medicine will become ineffective.

If you have any further questions on the use of this product, ask your doctor or pharmacist

Possible Side Effects

Like all medicines, CRIXIVAN can cause side effects, although not everybody gets them.

The following terms are used to describe how often side effects have been reported.

Very Common (occurring in at least 1 in 10 patients treated)

Common (occurring in at least 1 of 100 and less than 1 of 10 patients treated)

Not known (cannot be estimated from the available data)

Blood and lymphatic disorders:

Not known: low red blood cell count.

Immune system disorders:

Not known: allergic reactions (sometimes severe, including shock)

Nervous system disorders:

Very Common: dizziness; headache

Common: inability to sleep, decreased or abnormal skin sensation;

Not known: numbness of the mouth

Gastrointestinal disorders:

Very Common: nausea; vomiting; diarrhoea; an uncomfortable feeling in the stomach or belching after eating

Common: wind; dry mouth; acid regurgitation

Not known: inflammation of the pancreas; inflammation of the liver; liver failure

Skin and subcutaneous tissue disorders:

Very Common: dry skin; rash

Common: itching

Not known: severe skin reactions; hair loss; darkening skin colour; ingrown toenails with or without infection

Musculoskeletal connective tissue and bone disorders:

Common: muscle pain

Renal and urinary disorders:

Common: pain on urination

Not known: infection of the kidneys, decreased kidney function, loss of kidney function.

General disorders and administration site conditions:

Very Common: weakness/fatigue; taste perversion; abdominal pain/swelling

Ask your doctor or pharmacist for more information about side effects. Both have a more complete list of side effects.

There have been reports of inflammation of the kidneys and kidney stones. In some of these patients, this led to more severe kidney problems including kidney failure. In most cases, kidney impairment and kidney failure were reversible. Call your doctor if you develop sudden severe back pain, with or without blood in the urine, caused by kidney stones.

Your doctor will want to test your blood regularly to detect possible abnormalities such as rapid breakdown of red blood cells (anaemia), elevation of liver enzyme levels, impairment of kidney function, changes in blood sugar levels (hyperglycaemia).

In patients with haemophilia type A and B, there have been reports of increased bleeding while taking this treatment or another protease inhibitor. Should this happen to you, seek immediate advice from your doctor.

Inform your doctor as soon as possible if you develop severe muscle pain or weakness. Severe muscle pain and weakness have occurred in patients taking protease inhibitors, including CRIXIVAN, together with cholesterol–lowering medicines called “statins”. There have also been reports of muscle pain, tenderness or weakness, particularly with combination antiretroviral therapy including protease inhibitors and nucleoside analogues in patients not taking statins. On rare occasions these muscle disorders have been serious (rhabdomyolysis).

Combination antiretroviral therapy may cause changes in body shape due to changes in fat distribution. These may include loss of fat from legs, arms and face, increased fat in the abdomen (belly) and other internal organs, breast enlargement and fatty lumps on the back of the neck (‘buffalo hump’). The cause and long-term effects of these conditions are not known at this time. Combination antiretroviral therapy may also cause raised lactic acid and sugar in the blood, hyperlipidaemia (increased fats in the blood) and resistance to insulin.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How To Store Crixivan

Keep out of the reach and sight of children.

Do not use CRIXIVAN after the expiry date stated on the bottle or carton. The expiry date refers to the last day of the month.

Store CRIXIVAN in the original bottle. Keep the bottle tightly closed in order to protect from moisture. The bottles contain desiccant canisters that should remain in the bottle.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Further Information

What CRIXIVAN contains

• The active substance is indinavir sulphate. Each hard capsule contains indinavir sulphate corresponding to 200 mg of indinavir.


• The other excipients are anhydrous lactose, magnesium stearate, gelatin and titanium dioxide (E 171). The capsules are printed with printing ink containing indigo carmine (E 132).

What CRIXIVAN look like and content of the pack

CRIXIVAN 200 mg hard capsules are supplied in HDPE bottles with a polypropylene cap and a foil induction cap containing 180, 270 or 360 capsules. Not all pack sizes may be marketed.

The capsules are semi-translucent white and coded CRIXIVAN^TM 200 mg in blue.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder:

Merck Sharp & Dohme Limited

Hertford Road

Hoddesdon

Hertfordshire

EN11 9BU

United Kingdom

Manufacturer:

Merck Sharp & Dohme B.V.

Waarderweg 39

Postbus 581

2003 PC Haarlem

The Netherlands

For any information about this medicinal product, please contact the local representative of the Marketing Authorisation Holder.

United Kingdom

Merck Sharp and Dohme Limited

Tel:+44 (0) 1992 467272

medinfo_uk@merck.com

This leaflet was last approved in May 2010

Detailed information on this medicine is available on the European Medicines Agency (EMEA) web site: http://www.emea.europa.eu

denotes registered trademark of

Merck Sharp & Dohme Corp.

a subsidiary of

Merck & Co., Inc.

Whitehouse Station

NJ

USA

© Merck Sharp & Dohme Limited 2010. All rights reserved.

PIL.CRX200mg.10.UK.3267.IB-85

sodium phenylacetate and benzoate Intravenous

SOE-dee-um BEN-zoe-ate, SOE-dee-um fen-il-AS-e-tate

Commonly used brand name(s)

In the U.S.

• Ammonul

Available Dosage Forms:

• Solution

Therapeutic Class: Hyperammonemia Agent

Uses For sodium phenylacetate and benzoate

Sodium phenylacetate and benzoate injection combination is used to treat hyperammonemia, which is a condition where there is too much ammonia in the blood. Ammonia is formed from the breakdown of protein in the body. If the ammonia cannot be removed by the body, high amounts in the blood may cause serious unwanted effects. sodium phenylacetate and benzoate works to reduce the amount of ammonia in the blood.

sodium phenylacetate and benzoate is to be given only by or under the direct supervision of a doctor.

Before Using sodium phenylacetate and benzoate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For sodium phenylacetate and benzoate, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to sodium phenylacetate and benzoate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of sodium phenylacetate and benzoate injection in children.

Geriatric

Although appropriate studies on the relationship of age to the effects of sodium phenylacetate and benzoate injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving sodium phenylacetate and benzoate injection.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of sodium phenylacetate and benzoate. Make sure you tell your doctor if you have any other medical problems, especially:

• Congestive heart failure or


• Edema (swelling) or


• Hyperglycemia (high blood sugar) or


• Hypokalemia (low potassium in the blood) or


• Seizures (convulsions), history of—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of sodium phenylacetate and benzoate

A nurse or other trained health professional will give you or your child sodium phenylacetate and benzoate in a hospital. sodium phenylacetate and benzoate is given through a needle placed in one of your veins.

Your doctor will give you or your child a few doses of sodium phenylacetate and benzoate until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

It is also important that you follow any special diet instructions from your doctor, such as using a low protein diet. If you have any questions about this, check with your doctor.

Precautions While Using sodium phenylacetate and benzoate

It is very important that your doctor check your or your child's progress closely while you are receiving sodium phenylacetate and benzoate to make sure the medicine is working properly. Blood tests may be needed to check for unwanted effects.

sodium phenylacetate and benzoate may cause unwanted effects on the nervous system. Check with your doctor right away if you or your child have lightheadedness, muscle tingling or weakness, sleepiness or unusual drowsiness, or tiredness.

Check with your doctor right away if you or your child have more than one of the following symptoms while receiving sodium phenylacetate and benzoate: confusion; deep or fast breathing with dizziness; muscle tremors; nausea; numbness of the feet, hands, and around the mouth; rapid, deep breathing; restlessness; stomach cramps; or unusual tiredness or weakness.

sodium phenylacetate and benzoate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Abdominal or stomach pain or cramps


• blurred vision


• decreased urine


• dry mouth


• fatigue


• flushed, dry skin


• fruit-like breath odor


• increased hunger


• increased thirst


• increased urination


• irregular heartbeat


• loss of appetite


• muscle pain or cramps


• nausea or vomiting


• numbness or tingling in the hands, feet, or lips


• seizures


• shortness of breath


• sweating


• troubled breathing


• unexplained weight loss


• unusual tiredness or weakness

Less common

• Agitation


• anxiety


• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site


• bleeding or oozing from the puncture site, mouth, or nose that continues


• bloody or cloudy urine


• bloody, black, or tarry stools


• confusion


• coughing that sometimes produces a pink frothy sputum


• depression


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• drowsiness


• feeling, seeing, or hearing things that are not there


• feeling that others are watching you or controlling your behavior


• headache


• lightheadedness


• mood or mental changes


• muscle tremors


• nightmares or unusually vivid dreams


• pale skin


• rapid, deep breathing


• restlessness


• skin rash


• sleepiness or unusual drowsiness


• trouble with breathing when moving or walking


• unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Diarrhea


• fever

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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Atazanavir

Pronunciation: A-ta-ZAN-a-vir
Generic Name: Atazanavir
Brand Name: Reyataz

Taking Atazanavir with other medicines may result in serious or life-threatening side effects. Ask your doctor or pharmacist if you have any questions about which medicines should not be taken with Atazanavir.

Atazanavir is used for:

Treating HIV infection along with other medicines.

Atazanavir is an HIV protease inhibitor. It works by inhibiting HIV protease, which is the enzyme required to form functional proteins in HIV-infected cells.

Do NOT use Atazanavir if:

• you are allergic to any ingredient in Atazanavir


• you are taking alfuzosin, certain benzodiazepines (eg, oral midazolam, triazolam), cisapride, an ergot derivative (eg, ergotamine), certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), indinavir, irinotecan, nevirapine, pimozide, rifampin, salmeterol, or St. John's wort


• you are taking sildenafil for pulmonary arterial hypertension (PAH)


• you are taking voriconazole and you take ritonavir along with Atazanavir


• you are taking bosentan (unless you also take ritonavir along with Atazanavir)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Atazanavir:

Some medical conditions may interact with Atazanavir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a blood disorder (eg, hemophilia), diabetes, heart problems (eg, atrioventricular block), or liver problems (including hepatitis B or hepatitis C)


• if you have kidney problems or are on dialysis

Some MEDICINES MAY INTERACT with Atazanavir. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Certain benzodiazepines (eg, oral midazolam, triazolam), cisapride, ergot derivatives (eg, ergotamine), pimozide, or salmeterol because serious side effects, such as breathing problems, blood vessel problems, or irregular heartbeat, may occur


• Certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin) because the risk of serious muscle effects may be increased


• Alfuzosin because the risk of severe low blood pressure may be increased


• Indinavir because it may increase the risk of Atazanavir's side effects


• Bosentan (unless you also take ritonavir with Atazanavir), nevirapine, rifampin or, St. John's wort because they may decrease Atazanavir's effectiveness


• Irinotecan or sildenafil (when used for PAH) because the risk of its side effects may be increased by Atazanavir


• Voriconazole (if you take ritonavir along with Atazanavir) because its effectiveness may be decreased


• Many prescription and nonprescription medicines (eg, used for aches and pains, angina, asthma, birth control, blood pressure, blood thinning, cancer, depression, erectile dysfunction, heartburn or reflux disease, gout, immune system suppression, infections, inflammation, irregular heartbeat, heart problems, high blood pressure, high cholesterol, HIV, mental or mood problems, migraine, opioid addiction, pain, PAH, overactive bladder, seizures, sleep aid), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may interact with Atazanavir, increasing the risk of side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Atazanavir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Atazanavir:

Use Atazanavir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Atazanavir. Talk to your pharmacist if you have questions about this information.


• Take Atazanavir by mouth with food.


• Swallow Atazanavir whole. Do not break, crush, or chew before swallowing.


• Take Atazanavir on a regular schedule to get the most benefit from it.


• Taking Atazanavir at the same time each day will help you remember to take it.


• If you also take a proton pump inhibitor (eg, omeprazole), take it about 12 hours before you take Atazanavir.


• If you also take an H₂ antagonist (eg, cimetidine), talk with your doctor about how to take it with Atazanavir.


• If you also take an antacid or didanosine, take Atazanavir at least 2 hours before or 1 hour after the antacid or didanosine.


• Continue to use Atazanavir even if you feel well. Do not miss any doses.


• If you miss a dose of Atazanavir, take it as soon as possible. If it is within 6 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Atazanavir.

Important safety information:

• Atazanavir may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Atazanavir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Atazanavir is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.


• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Atazanavir, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.


• Atazanavir does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.


• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Atazanavir. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Atazanavir. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Atazanavir may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of an infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start Atazanavir.


• Atazanavir may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.


• Diabetes patients - Atazanavir may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Lab tests, including liver function, bilirubin levels, lipid or cholesterol levels, and electrocardiograms, may be performed while you use Atazanavir. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Atazanavir with caution in the ELDERLY; they may be more sensitive to its effects.


• Atazanavir should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• Atazanavir should not be used in CHILDREN younger than 3 months old; a type of brain damage caused by high blood bilirubin levels (kernicterus) may occur.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Atazanavir while you are pregnant. It is not known if Atazanavir is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Atazanavir to the baby.

Possible side effects of Atazanavir:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in body fat; cough; diarrhea; fatigue; headache; increased cough; muscle pain; nausea; pain; stomach pain; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; chest pain; dizziness; fever, chills, or sore throat; increased urination or thirst; irregular heartbeat; lightheadedness; mental or mood changes (eg, depression); numbness, tingling, or extreme weakness especially in the arms or legs; painful urination; red, blistered, or swollen skin; severe nausea or vomiting; severe stomach or side pain; trouble breathing; unusual bleeding or bruising; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Atazanavir side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe dizziness and lightheadedness; yellowing of the eyes or skin.

Proper storage of Atazanavir:

Store Atazanavir at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Atazanavir out of the reach of children and away from pets.

General information:

• If you have any questions about Atazanavir, please talk with your doctor, pharmacist, or other health care provider.


• Atazanavir is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Atazanavir. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Atazanavir resources

• Atazanavir Side Effects (in more detail)
• Atazanavir Use in Pregnancy & Breastfeeding
• Atazanavir Drug Interactions
• Atazanavir Support Group
• 1 Review for Atazanavir - Add your own review/rating

• atazanavir Advanced Consumer (Micromedex) - Includes Dosage Information


• Atazanavir Sulfate Monograph (AHFS DI)


• Reyataz Prescribing Information (FDA)


• Reyataz Consumer Overview

Compare Atazanavir with other medications

• HIV Infection
• Nonoccupational Exposure